likely if you run into trouble after installing one or more new mods. It is fairly complex, very powerful, and not exactly intuitive, so read the documentation and tutorials when trying to use it. If youre experiencing a launching problem in The Elder Scrolls V: Skyrim Special. Wyre Bash (Oblivion) is typically required for any moderately complex Oblivion game, MO2 has some support I believe, while Vortex doesn't as far as I know beyond their general 'Add Tool' option. Some are loose files bundled in a generic archive (zip or rar), some are for older mod managers. That said with Oblivion you can encounter mods that are not packed for modern mod organizers. The last time I played Oblivion, was my Steam version of Oblivion modded primarily via Vortex, with OBSE (before xOBSE was released). This keeps the game from having a mix of files managed by the mod manager and manually copied. To install the script extender using the Vortex mod manager (via its already included extension). VORTEX - Beginner's Guide #7 : Script Extenders (video by Gopher).

With current version of Vortex you can follow

Launch mod organizer through steam